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孢子丝菌病一般只局限于皮肤,但现今已发现了不少全身感染的患者,尤其多见于免疫抑制的病人。以往,对孢子丝菌病的免疫学机制了解尚不充分。作者采用申克氏孢子丝菌的可溶性抗原(AgS)对全身感染的小鼠的细胞免疫作了研究。用含有10~7细胞/ml 申克氏孢子丝菌孢子悬液经静脉和腹腔感染 Swiss 小鼠;然后用经超声处理此菌酵母相制备的 AgS 作体内迟发超敏试验(足垫试验),并作切片检查。同时,使用 AgS 和刀豆球蛋白-A(Con-A)进行感染小鼠脾
Sporotrichosis is generally confined to the skin, but many systemic infections have now been found, especially in immunocompromised patients. In the past, understanding of the immunological mechanism of sporotrichosis is not yet fully understood. The authors studied the cellular immunity of mice that were fully infected with soluble antigens (AgS) from Spirulina Shinseiki. Swiss mice were infected intravenously and intraperitoneally with Sporangium sp. Suspension containing 10-7 cells / ml; followed by in vivo delayed hypersensitivity test (footpad test) with AgS prepared by sonication of the yeast yeast phase , And for biopsy. In the meantime, mouse spleen was infected with AgS and concanavalin-A (Con-A)