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5-,6-,7-硝基取代的3-吲(口乃木)乙酸已分别由Cavallini,Brown,Hiremath与他们的合作者合成。本文报告从4-硝基吲(口乃木)通过相应的3-二甲氨代甲基吲(口乃木)(芦竹碱),按标准步骤合成4-硝基-3-吲(口乃木)乙酸。 Berti等曾用3-二甲氨代甲基吲(口乃木)直接硝化的方法制得4-硝基-3-二甲氨代甲基吲(口乃木)(4-硝基芦竹碱),熔点120—122°,产率很低。我们按照Parmerter等的方法制备4-硝
5-, 6-, 7-Nitro-substituted 3-indo (noggin) acetic acid has been synthesized by Cavallini, Brown, Hiremath and their collaborators, respectively. This paper reports the synthesis of 4-nitro-3-indole (nocturnal ginseng) according to standard procedures starting from 4-nitroindole (nociceporum) via the corresponding 3-dimethylaminomethylindane Acetic acid. Berti et al. Used 4-nitro-3-dimethylaminomethylindole (noradrenaline) (4-nitroprusside) by the direct nitration of 3-dimethylaminomethylindole , Melting point 120-122 °, the yield is very low. We prepared 4-nitro according to the method of Parmerter et al