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目的检测非受体蛋白质酪氨酸磷酸酶14(PTPN14)蛋白在胆管癌组织中的表达,探讨PTPN14与胆管癌临床病理特征间的关系,并分析PTPN14的表达与胆管癌患者预后的关系。方法用免疫组织化学染色检测胆管癌组织及癌旁组织中PTPN14蛋白的表达;利用统计学分析软件分析PTPN14蛋白与胆管癌患者临床病理特征之间的关系;利用生存分析曲线分析PTPN14蛋白与胆管癌患者术后5年生存率的关系。结果 PTPN14蛋白在胆管癌组织中的阳性表达率为49.1%,在癌旁组织中的阳性表达率为75.4%;PTPN14蛋白的表达与胆管癌临床分期及分化程度密切相关,与胆管癌患者性别、年龄无显著相关性;PTPN14蛋白阳性表达的胆管癌患者术后5年生存率显著高于阴性表达的患者。结论 PTPN14在胆管癌组织低表达,且PTPN14低表达与胆管癌的良性临床病理特征及总体生存率呈负相关。
Objective To detect the expression of PTPN14 protein in cholangiocarcinoma and to explore the relationship between PTPN14 and clinicopathological features of cholangiocarcinoma and to analyze the relationship between the expression of PTPN14 and the prognosis of cholangiocarcinoma. Methods Immunohistochemical staining was used to detect the expression of PTPN14 protein in cholangiocarcinoma tissues and paracancerous tissues. Statistical analysis software was used to analyze the relationship between PTPN14 protein and clinicopathological features of cholangiocarcinoma patients. The survival analysis curve was used to analyze the relationship between PTPN14 protein and cholangiocarcinoma 5-year survival rate of patients after the relationship. Results The positive expression rate of PTPN14 protein in cholangiocarcinoma was 49.1%, while it was 75.4% in para-cancerous tissues. The expression of PTPN14 protein was closely related to the clinical stage and differentiation of cholangiocarcinoma, There was no significant difference in age between two groups. The 5-year survival rate of patients with PTPN14-positive cholangiocarcinoma was significantly higher than that of patients with negative expression. Conclusions PTPN14 is overexpressed in cholangiocarcinoma tissue, and the low expression of PTPN14 is negatively correlated with the benign clinicopathological features and overall survival rate of cholangiocarcinoma.