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肠道菌引起的肠壁炎症常伴发关节炎症。动物实验表明,肠道内专性厌氧菌细胞壁片段(CWF)中的肽聚糖-脂多糖(PG-PS)为诱发关节炎的主要成分。人肠内容物可溶相和哺乳动物组织中均有PG-PS或其亚单位存在。由细菌PG-PS诱发的关节炎完全依赖于功能性T细胞。类风湿性关节炎(RA)是一种针对抗原提呈细胞的主要组织相容性复合物上小分子肽的T细胞依赖过程。因此,抗PG肽免疫反应在原因不明的人类关节炎中起着重要作用。
Intestinal bacteria caused by intestinal inflammation often accompanied by joint inflammation. Animal experiments show that peptidoglycan-lipopolysaccharide (PG-PS) in the intestine obligate anaerobic cell wall fragment (CWF) is the main component inducing arthritis. PG-PS or its subunits are present in both human intestinal contents and in mammalian tissues. Arthritis induced by the bacterial PG-PS is completely dependent on functional T cells. Rheumatoid arthritis (RA) is a T-cell dependent process directed against small peptides on the major histocompatibility complex of antigen presenting cells. Therefore, anti-PG peptide immune responses play an important role in human arthritis of unknown cause.