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目的 本文对大骨节病（ＫＢＤ）病儿外周血等血细胞进行了形态学观察以便和ＫＢＤ病尸骨髓血细胞坏死病变相对照。方法 在临床Ｘ线普查基础上，采病儿外周血及骨髓吸出物涂片、Ｗｒｉｇｈｔ－Ｇｉｅｍｓａ染色、光镜观察。结果 在部分外周血白细胞及骨髓血细胞的核染色质粒间出现淡紫红色点状物伴其周染色质溶解，进而点状物融合形成斑块，直至整个核转化为均质大团块。外周血白细胞病变阳性例的检出率占病区受检例总数的８３．１％。讨抡和结论 白细胞等核内出现的点状物、斑块和团块都应是核内病毒包涵体；病儿外周血白细胞坏死与ＫＢＤ病尸骨髓血细胞坏死、软骨细胞Ｂ型凝固性坏死是性质同一的病理过程，都是ＫＢＤ病理变化的一部分，三者坏死病变可能都是ＫＢＤ的同一病毒病因所引起。
Objective This article was performed on Kashin-Beck disease (KBD) children with peripheral blood and other blood cells were morphologically observed in order to KBD disease and bone marrow necrosis compared with the blood. Methods On the basis of clinical X-ray screening, peripheral blood and bone marrow aspirate smear from diseased children were stained with Wright-Giemsa and observed with light microscope. Results In some peripheral blood leukocytes and bone marrow blood cells nuclear staining plasmids appeared purple spots with their week of chromatin dissolution, and then point the formation of plaques fusion, until the entire nucleus into a homogeneous mass. The positive rate of peripheral leukocytosis cases accounted for 83.1% of the total cases in the ward. Discussion and Conclusion Leukocyte and other nuclei appear in the spots, plaques and clumps should be the nucleus of the virus inclusions; sick children with peripheral leukocyte necrosis and KBD disease dead necrosis of bone marrow cells, chondrocytes B-type coagulation necrosis is The same nature of the pathological process are pathological changes in KBD part of the three necrotic lesions may be caused by the same virus KBD cause.