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用缺Ｓｅ缺Ｉ的克山病病区粮为基础，分别添加Ｓｅ或／和Ｉ的饲料喂养４组大鼠。测定了心肌组织Ｓｅ和Ｔ３水平，α－ＧＰＤ、ＩＤＩ、ＧＰｘ活力以及血浆Ｔ４、Ｔ３水平。结果发现，缺Ｉ使大鼠血浆Ｔ４显著下降，而缺Ｓｅ又使适Ｉ大鼠血浆Ｔ４水平增高。所有４组血浆Ｔ３水平波动幅度不大。心肌未能测出ＩＤＩ活性，心肌Ｓｅ含量因饲料加Ｓｅ而增高，但没有影响心肌Ｔ３水平。心肌α－ＧＰＤ活性缺Ｉ组明显低于加Ｉ组，并与血浆Ｔ４水平高度正相关，而与心肌ＧＰｘ活性关系不明显。研究提示，克山病病区粮引起的大鼠心肌低能量代谢特点与缺Ｉ或缺Ｉ引起的ＴＨ代谢异常有明显关系。
Using the food lacking Se-deficient Keshan disease, four groups of rats were fed with Se or / and I respectively. Myocardial tissue Se and T3 levels, α-GPD, IDI, GPx activity and plasma T4, T3 levels were measured. The results showed that the lack of I significantly decreased plasma T4 in rats, and lack of Se in turn suitable I rat plasma T4 levels increased. All four plasma T3 levels fluctuate less. IDI activity was not detected in myocardium, while Se content in myocardium was increased due to diet plus Se, but did not affect myocardial T3. Myocardial α-GPD activity was significantly lower in I-deficient group than in I group, and was positively correlated with plasma T4 level, but not with myocardial GPx activity. Studies suggest that Keshan disease ward-induced myocardial metabolic characteristics of low-energy myocardial ischemia and lack of I-induced TH metabolic abnormalities have a clear relationship.