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３１例各种晚期上消化道恶性肿瘤患者，以生长方式分为隆起型（１７例），平坦型（１０例）和溃疡型（４例）。在内镜下以丝裂霉素，５－氟脲嘧啶，羟基喜树碱等药于病灶处行局部化疗。结果示：患者梗阻症状明显改善，尤以肿块型为最显著（Ｐ＜０．０１）；中位生存期延长至（１２．４±４．７）月，没有出现明显的副作用及并发症，结合使用肿瘤坏死因子，微波治疗可提高疗效。结果表明：对于不能手术的晚期上消化道恶性肿瘤患者，内镜下局部化疗是一种有效而无副作用的姑息疗法
Thirty-one patients with various advanced upper digestive tract malignancies were divided into bulge type (17 cases), flat type (10 cases) and ulcer type (4 cases). Endoscopic chemotherapy with mitomycin, 5-fluorouracil, hydroxycamptothecin and other drugs was performed on the lesions. The results showed that the symptoms of obstruction were significantly improved, especially in the mass type (P<0.01); the median survival time was extended to (12.4±4.7) months without obvious side effects and complications. In combination with tumor necrosis factor, microwave therapy can improve the efficacy. The results show that endoscopic local chemotherapy is an effective palliative treatment without side effects for patients with inoperable advanced upper digestive tract malignancies