基于蛋白酪氨酸激酶为靶点的抗癌试剂的结构特点,设计与合成了系列含哌嗪基的噻吩并[3,2-d]嘧啶衍生物。以巯基乙酸为原料,经酯化、两次缩合成环、氯代等4步反应得4-氯噻吩并[3,2-d]嘧啶母核,再与不同的哌嗪衍生物在DMF中发生亲核取代反应,制备了4个未见报道的含哌嗪基噻吩并[3,2-d]嘧啶化合物,产物结构经1HNMR和HRMS表征。 Based on the structural features of anti-cancer agents targeting protein tyrosine kinases, a series of piperazinyl-containing thieno [3,2-d] pyrimidine derivatives were designed and synthesized. 4-chlorothieno [3,2-d] pyrimidine was obtained from thioacetic acid by esterification, condensation twice, ring condensation and chlorination in 4 steps, and then reacted with different piperazine derivatives in DMF Four nucleophilic substitution reactions were carried out to prepare four previously reported piperazinylthieno [3,2-d] pyrimidine compounds. The product structure was characterized by 1HNMR and HRMS.