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为验证每三个月注射一次的醋酸甲孕酮避孕针(狄波-普维拉),是否适于中国妇女应用,1995年10月起在上海市区(县)7家医院试用,共接纳451例,其中哺乳期208例,非哺乳对象243例,共使用3708妇女月,有效率100％,一年期因症停用率39％,因社会因素停用15.7％,早期副反应以滴血及少量不规则出血为主,后期闭经发生率上升,以90天为月经记录参照时期,第一至第四参照时期出血(滴血)过长,人数由65.8％降至23.3％,闭经人数由6.2％升至45.2％,未发生严重并发症;哺乳期或35岁以下妇女副反应发生率低于非哺乳或年龄≥35岁者(P<0.05),证明醋酸甲孕酮为高效、长效、安全、方便的避孕措施,尤其适宜于产后42天妇女使用,可减少产后早期及哺乳期人工流产,更适用于反复避孕失败的年轻妇女。
In order to verify the suitability of injectable medroxyprogesterone acetate tablets (Debo-Puvira) once every three months for Chinese women, the trial was conducted in seven hospitals in Shanghai (county) since October 1995, 451 cases, of which 208 cases of lactation, non-lactating 243 cases, a total of 3708 women with a month, the effective rate of 100%, 39% of the one-year disease discontinuation rate of 15.7% disabled due to social factors, early side effects with drops Blood and a small amount of irregular bleeding, the incidence of amenorrhea after the rise to 90 days for the menstrual record reference period, the first to the fourth reference period bleeding (bleeding) is too long, the number decreased from 65.8% to 23.3%, the number of amenorrhea From 6.2% to 45.2%, no serious complications occurred. The incidence of side effects in lactating women or those under 35 years old was lower than that of non-lactating women or those aged 35 years or older (P <0.05), proving that medroxyprogesterone acetate was effective and long Effective, safe and convenient contraception, especially for women 42 days postpartum, can reduce postpartum and lactation induced abortion, more suitable for repeated contraception failure of young women.