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氯甲酸酯(ClCO_2R,R=Et,C_6H_5)与混合Grignard试剂(R_1MgBr、溴化亚酮和溴化锂组成)在THF中,室温反应15h,经交叉耦合反应可合成酯(R_1CO_2R),化学选择性高。9例收率60%～98%。
The reaction of chloroformate (ClCO_2R, R = Et, C_6H_5) with mixed Grignard reagent (R_1MgBr, brominated ketone and lithium bromide) was carried out in THF at room temperature for 15h. high. Nine cases of 60% to 98% yield.