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目的探讨焦炉作业工人血清中丙二醛(MDA)及尿β2-微球蛋白(β2-MG)的水平及意义。方法选择106名焦炉作业工人作为接触组,72名无任何职业有害物质接触史的体检者作为对照组。采集空腹静脉血和尿样,用试剂盒检测血清MDA和尿β2-MG水平。结果与对照组比较,接触组焦炉工血清MDA水平明显增高;经尿肌酐校正后的尿β2-MG水平高于对照组,差异有统计学意义(P<0.05)。在接触组中,炉顶工血MDA和尿β2-MG水平均高于炉侧工和炉底工,差异有统计学意义(P<0.05)。178名调查者血MDA和尿β2-MG呈正相关。结论焦炉逸散物可导致焦炉工人生物膜氧化损伤和早期的肾损害,可以把血清MDA和尿β2-MG一起作为焦炉工人职业损害的检测指标。
Objective To investigate the level and significance of serum malondialdehyde (MDA) and urinary β2-microglobulin (β2-MG) in coke oven workers. Methods 106 coke oven workers were selected as the contact group, and 72 subjects who had no contact history of occupational harmful substances were selected as the control group. Fasting venous blood and urine samples were collected, serum MDA and urinary β2-MG levels were detected by kit. Results Compared with the control group, the level of serum MDA in the exposed coke oven workers was significantly higher than that of the control group. The urinary β2-MG level corrected by urinary creatinine was significantly higher than that in the control group (P <0.05). In the exposure group, the levels of MDA and urinary β2-MG in the top of the blood were higher than those in the side and bottom of the furnace, the difference was statistically significant (P <0.05). 178 investigators blood MDA and urine β2-MG was positively correlated. Conclusion Coke oven fugitives can lead to oxidative damage and early renal damage to coke oven workers’ biofilms. Serum MDA and urinary β2-MG can be used as indicators of occupational injury in coke oven workers.