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目的观察静脉应用胺碘酮对阵发性心房颤动的疗效。方法 61例阵发性房颤的患者,首剂静脉注射150mg,10min内注入,继之以0.5mg/分维持静脉泵入,30min未转复为窦性心律且心室率仍快者,追加静脉注射150mg。结果 15例4小时内转复窦性心律,18例4～12小时后转复窦性心律,13例12～48小时后转复窦性心律。转复率为83.6%;用药期间,2例出现窦性心动过缓,无低血压、心衰加重、心绞痛加重及QT间期延长等不良反应。结论静脉应用胺碘酮治疗阵发性心房颤动安全有效。
Objective To observe the effect of intravenous amiodarone on paroxysmal atrial fibrillation. Methods Sixty-one patients with paroxysmal atrial fibrillation were injected with the first dose of 150 mg intravenously in 10 minutes, followed by intravenous infusion of 0.5 mg / minute, sinus rhythm in 30 minutes and rate of ventricular rate was still faster, the additional vein Injection 150mg. Results In 15 cases, sinus rhythm was recovered within 4 hours, sinus rhythm was restored in 18 cases from 4 to 12 hours, and sinus rhythm was restored in 13 cases from 12 to 48 hours. The conversion rate was 83.6%. During the treatment period, 2 patients had sinus bradycardia, no hypotension, increased heart failure, aggravated angina and prolonged QT interval. Conclusion Intravenous amiodarone is safe and effective in the treatment of paroxysmal atrial fibrillation.