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p53基因是人类肿瘤发生、发展中的一个重要的抑癌基因,p53基因的突变、失活及缺失与50 %的人类肿瘤有关,它是脑胶质瘤发生中一个最常见的基因改变之一。研究表明在肿瘤的发生中p53不是独立发挥抑癌作用,它需要与其上、下游基因协同发挥作用。本文综述了p53相关基因的最新进展及在胶质瘤发生、发展中的作用。
The p53 gene is an important tumor suppressor gene in the development and progression of human tumors. The mutation, inactivation and deletion of the p53 gene are associated with 50% of human tumors. It is one of the most common gene changes in the development of glioma . Studies have shown that p53 does not function as a tumor suppressor independently in tumorigenesis, and it needs to work synergistically with its upstream and downstream genes. This review summarizes the latest progress of p53 related genes and its role in the development and progression of glioma.