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硝普钠直接作用于血管平滑肌,能使血管扩张,血压迅速下降,周围阻力相应减小,同时冠脉灌流量加大,心肌供氧改善;停药后血压回升快,一般都不需使用升压药。关于硝普钠的降压性能,早在1928年之前已有所知,毕竟因其有一定的毒性,药典尚未认可。1966年以来,临床上先后使用于高血压和心血管病的治疗。尤其是作为麻醉期间控制性降压,应用于颅内动脉瘤和嗜铬细胞瘤(对d受体阻断剂具有耐药的病人)
Sodium nitroprusside directly on the vascular smooth muscle, can make the blood vessels to dilate, rapid decline in blood pressure, the corresponding reduction in resistance around the same time, increased coronary perfusion, myocardial oxygen supply improved; withdrawal of blood pressure rise quickly, generally do not need to use l Pressure medicine. The depressurization performance of sodium nitroprusside, as early as 1928 already known, after all, because of its certain toxicity, Pharmacopoeia has not been recognized. Since 1966, clinically used in the treatment of hypertension and cardiovascular diseases. Especially as a controlled antihypertensive during anesthesia, applied to intracranial aneurysms and pheochromocytoma (patients resistant to d receptor blockers)