近来,基于流行病学和病毒学证据,外阴癌可分为病因学上完全不同的两组,一组占外阴癌中小部分,发生于年轻妇女,组织学上呈基底细胞样或疣状,并存在有邻近的外阴上皮内瘤样变(VIN),人类乳头瘤病毒(HPV)DNA呈阳性;另一组为占外阴癌大部分的老年人。已有研究证明HPV感染是VIN及基底细胞样/疣状外阴癌的有关致病因素,HPV已知的E_6、E_7癌基因的表达能破坏细胞周期调节功 Recently, on the basis of epidemiological and virological evidence, vulvar cancer can be divided into two groups of etiologically completely different groups, a small group of vulvar cancers, a small group of young women, histologically basal-like or verrucous, and There are adjacent cases of vulvar intraepithelial neoplasia (VIN), human papillomavirus (HPV) DNA positive; the other group is accounted for the majority of vulvar cancer in the elderly. Studies have shown that HPV infection is a related causative agent of VIN and basaloid / verrucous vulvar cancer. The expression of E_6 and E_7 oncogenes known by HPV can disrupt cell cycle regulation