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双氯芬酸钠(diclofenac sodium,双氯灭痛)是第三代强效邻氨基苯甲酸类非甾体消炎镇痛药。近几年其外用制剂及缓释剂得到研究应用,现综述如下: 1 缓释制剂 1.1 缓释片 为减少双氯芬酸钠的胃肠道不良反应并延长其作用时间,近几年其缓释制剂研究较多。何圣鑫以魔芋精粉作为缓释辅料研制的双氯芬酸缓释片,在人工胃液中12 h溶出度<10％,且主要在肠道内释放,若魔芋精粉用量增加,双氯芬酸钠溶出即减少。屈步华,李德平,徐学银,等研制的甲壳素-双氯芬酸缓释片对角叉菜胶诱发的SD大鼠棉球肉芽肿有显著的抑制作用,且药效维持时间长。李爱民,邹恒琴,张忠义,等以羟丙基甲基纤维素
Diclofenac sodium (diclofenac sodium) is the third generation of non-steroidal anthranilic acid anti-inflammatory analgesic. In recent years, its topical formulations and sustained release agents have been studied and applied, are summarized as follows: 1 sustained release preparations 1.1 sustained release tablets To reduce the adverse reactions of diclofenac sodium gastrointestinal tract and prolong its duration of action, its sustained release preparations in recent years More. He Shengxin to Konjac flour as sustained release materials developed diclofenac sustained-release tablets, 12 h in artificial gastric juice dissolution of <10%, and mainly released in the intestine, if the increase in the amount of konjac flour, diclofenac sodium dissolution is reduced. Qu Beihua, Li Deping, Xu Xueyin, such as the development of chitin - diclofenac sustained release tablets of carrageenan induced by rat carrageenan granuloma significantly inhibited, and the efficacy of maintaining a long time. Li Aimin, Zou Hengqin, Zhang Zhongyi, etc. to hydroxypropyl methyl cellulose