论文部分内容阅读
给链脲霉素性糖尿病大鼠喂食Sorbinil5mg和20mg/kg共18天,可改善尾神经传导速度,降低坐骨神经和晶体内山梨醇水平,对血糖水平无明显的影响。给喂食半乳糖大鼠,口服Sorbinil 10和25 mg/kg。每日2次,可防止晶体混浊。大于2×10~(-6)M时,可抑制离体大鼠晶体的白内障形成。小鼠用二硝基氟苯滴耳,同时口服Sorbinil,开始二日可抑制延迟性过敏性反应,本品每日20 mg/kg治疗8周,可防止链脲霉素性糖尿病大鼠肌的肌醇浓度减少和大鼠颈上神经节Na~+/K~+-ATP酶活性的降低。 Sorbinil治疗链脲霉素糖尿病大鼠,可防
To streptozotocin diabetic rats feeding Sorbinil5mg and 20mg / kg for a total of 18 days, can improve the conduction velocity of the cauda equina, reduce the sciatic nerve and intracranial sorbitol levels, no significant effect on blood glucose levels. To rats fed galactose, oral administration of Sorbinil 10 and 25 mg / kg. 2 times a day to prevent crystal opacity. When it is more than 2 × 10 -6 M, cataract formation in isolated rat crystals can be inhibited. The mice with dinitrofluorobenzene ear drops, while oral administration of Sorbinil, the first two days to inhibit delayed anaphylactic reaction, the goods daily 20 mg / kg treatment for 8 weeks to prevent streptozotocin diabetic rat muscle Reduced inositol concentration and decreased Na ~ + / K ~ + -ATPase activity in rat superior cervical ganglion. Sorbinil treatment of streptozotocin in diabetic rats, preventable