论文部分内容阅读
目的探讨卡维地洛治疗慢性心力衰竭(CHF)的疗效及对血浆脑钠肽及细胞因子的影响。方法将80例CHF患者分为对照组和观察组各40例,对照组应用血管紧张素转化酶抑制剂、利尿剂等治疗,观察组在常规治疗基础上加用卡维地洛。治疗12周后观察两组疗效及血浆脑钠肽和细胞因子水平。结果治疗12周后观察组总有效率显著高于对照组(P<0.05),心功能指标LVEDd、LVFF及血浆脑钠肽、细胞因子与对照组比较差异有统计学意义。结论卡维地洛治疗CHF疗效显著,可改善患者心功能,降低血浆脑钠肽和细胞因子的水平。
Objective To investigate the curative effect of carvedilol on chronic heart failure (CHF) and its effect on plasma brain natriuretic peptide and cytokines. Methods 80 cases of CHF patients were divided into control group and observation group of 40 cases, the control group with angiotensin converting enzyme inhibitors, diuretics and other treatment groups in the observation group on the basis of conventional treatment with carvedilol. After 12 weeks of treatment, the curative effect of both groups and the levels of plasma brain natriuretic peptide and cytokines were observed. Results After 12 weeks of treatment, the total effective rate in observation group was significantly higher than that in control group (P <0.05). There was significant difference in LVEDd, LVFF, plasma BNP and cytokines between the observation group and the control group. Conclusion Carvedilol treatment of CHF significant effect, can improve cardiac function, reduce plasma levels of brain natriuretic peptide and cytokines.