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目的探讨对消化系统疾病患者在伴有腹水情况下检测其糖类抗原(carbohydrate antigen)153(CA153)、199(CA199)、125(CA125)以及腹水癌胚抗原(CEA)等肿瘤标志物在诊断过程中的临床应用价值。方法选取良性及恶性腹水患者各40例作为参照组和观察组,采用电化学发光法测定其腹水与血清中CA153、CA199、CA125以及CEA四种标志物,同时以检测对象工作特性(ROC)曲线为依据确定临床判定临界值并确保其最为合理。结果恶性腹水患者在四种标志物指数水平上均较良性腹水明显更高,组间差异有统计学意义;在观察组中,患者血清中的四种标志物水平显著低于其在腹水中的含量;联合CA153与CEA检测过程中的特异性与敏感性分别为93.5%、97.7%。结论对伴有腹水的消化系统肿瘤患者,腹水CA199、CA153、CA125以及CEA四种肿瘤标志物的检测临床意义重大,而联合CA153和CEA检测为最佳检测方案。
Objective To investigate the diagnostic value of carbohydrate antigen 153 (CA153), 199 (CA199), 125 (CA125) and ascitic carcinoembryonic antigen (CEA) in patients with digestive system diseases with ascites. The clinical value of the process. Methods Forty patients with benign and malignant ascites were selected as the reference group and the observation group. Four markers of CA153, CA199, CA125 and CEA in ascites and serum were determined by electrochemiluminescence method. At the same time, the ROC curve As the basis for determining the critical value of clinical judgment and to ensure that it is the most reasonable. Results Malignant ascites patients were significantly higher than the benign ascites at four marker index levels, the difference between the two groups was statistically significant; in the observation group, the serum levels of four markers were significantly lower in patients with ascites Content. The specificity and sensitivity of the combination of CA153 and CEA were 93.5% and 97.7% respectively. Conclusion The detection of four tumor markers CA199, CA153, CA125 and CEA in patients with digestive system neoplasm associated with ascites is of great significance, while the combined detection of CA153 and CEA is the best detection method.