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华蟾素的药品名为华蟾素注射液(Cinobutacini injection,CINO)是我国临床中应用较广的抗肿瘤中药制剂,尤其对原发性肝癌、肺癌、食管癌等具有较好的疗效.近年来,中药华蟾素注射液治疗肝癌、肺癌、胰腺癌的 I 期临床研究已获得阶段成果,初步的实验结果显示,其抗肿瘤活性有效组分可能为其非极性部分.本文综述了华蟾素抑制肿瘤细胞的机制以及当今其用于各种癌症的研究的进展.“,”Cinobufagin drug cal ed cinobufacini injection ( Cinobutacini injection, ) is an antineoplastic which is widely used in clinical in China , especial y for primary liver cancer, lung cancer, esophageal cancer, has a good curative effect. Recently, Chinese traditional medicine of cinobufacini injection for the treatment of liver cancer, lung cancer, pancreatic cancer of phase I clinical studies has obtained stage achievement.The preliminary experiments shows that the anti-tumor’s active components maybe probably the non-polar component. In 2005,this project was financed by the American NCI U19,to carry on the treatment of pancreatic cancer in a phase I clinical study.This article reviews the cinobufagin inhibiting tumor cel mechanisms and now being used for a variety of cancer research progress.