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目的分析妊娠期高血压疾病并发HELLP综合征的临床表现及对母儿的影响,探讨有效的诊断和治疗方法。方法1996年1月至2004年3月中山市人民医院采用回顾性分析方法,对29例Ⅰ型和Ⅱ型HELLP综合征的临床资料进行分析,对比两组患者的临床表现、母儿并发症和分娩结局。结果Ⅰ型HELLP组的重度子疒间前期和子疒间发生率为94.7%,明显高于Ⅱ型HELLP组(50.0%)(P<0.05);Ⅰ型HELLP组出现特殊表现者占68.4%,亦高于Ⅱ型HELLP组(30.0%)(P<0.05);Ⅰ型HELLP组围生儿死亡率31.6%,Ⅱ型HELLP组围生儿死亡率10.0%,两组比较差异有显著性意义(P<0.05);两组间产妇并发症、剖宫产率比较差异无显著性意义(P>0.05)。两组患者血小板值产后72h恢复正常。结论早期诊断、综合性治疗、适时终止妊娠,可改善HELLP综合征患者的预后。
Objective To analyze the clinical manifestations of Hypertensive disorder complicating pregnancy and HELLP syndrome and its impact on maternal and child health and to explore effective methods of diagnosis and treatment. Methods From January 1996 to March 2004, Zhongshan People ’s Hospital adopted a retrospective analysis method to analyze the clinical data of 29 cases of type Ⅰ and type Ⅱ HELLP syndrome. The clinical manifestations, complications of both mother and child and Delivery ending. Results The incidence of severe prey and premature encephalon in type Ⅰ HELLP group was 94.7%, which was significantly higher than that in type Ⅱ HELLP group (50.0%) (P <0.05). Type Ⅰ HELLP group had 68.4% (P <0.05). The average perinatal mortality rate was 31.6% in type I HELLP group and 10.0% in type II HELLP group (P <0.05). There was significant difference between the two groups (P <0.05). There was no significant difference in maternal complications and cesarean section rate between the two groups (P> 0.05). Two groups of patients with platelet value returned to normal 72h postpartum. Conclusion Early diagnosis, comprehensive treatment, timely termination of pregnancy, can improve the prognosis of patients with HELLP syndrome.