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目的:探讨大连市新生儿先天性甲状腺功能减低症(CH)的5年筛查结果、CH发病情况及治疗效果,总结经验及体会。方法:对大连市出生的所有新生儿出生后采足跟血,制成干血滤纸片,采用时间分辨免疫荧光法(DELFIA)检测干血片中促甲状腺素(TSH)的水平,对于TSH>10μU/ml者作为可疑病例召回,用电化学发光法进行确诊。结果:大连市5年来共筛查新生儿154 047例,确诊CH患儿47例,确诊病人立即给予治疗,并定期监测体格和智能发育。结论:大连市CH发病率为0.305‰,基本符合国内CH总的发病趋势。新生儿疾病筛查工作开展以来,CH患儿都能够得到早期确诊,治疗效果满意。大连市的新生儿疾病筛查人群覆盖率已经达到98.27%,巩固现有成果,争取稳定发展是今后工作重点。
Objective: To investigate the 5-year screening results, CH morbidity and therapeutic effect of congenital hypothyroidism (CH) in neonates in Dalian and to summarize experience and experience. Methods: All newborns born in Dalian were taken blood and hematopoietic stems after birth to make dry blood filter paper. The levels of thyroid stimulating hormone (TSH) in dried blood tablets were detected by time-resolved immunofluorescence assay (DELFIA) 10μU / ml were recalled as suspicious cases, the use of electrochemiluminescence method for diagnosis. Results: A total of 154 047 newborns were screened in Dalian in the past five years. 47 confirmed CH children were diagnosed, and the patients diagnosed immediately were treated. Physical and mental development were regularly monitored. Conclusion: The incidence of CH in Dalian is 0.305 ‰, which is in line with the general incidence trend of CH in China. Neonatal disease screening work carried out, CH children can be diagnosed early, the treatment effect is satisfactory. Dalian population coverage of neonatal screening has reached 98.27%, to consolidate the existing achievements for stable development is the focus of work in the future.