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目的 探讨阿托伐他汀对间质纤维化大鼠肾间质巨噬细胞积聚的影响及其可能的机制。方法 2 1只大鼠随机分为假手术、单侧输尿管梗阻 (UUO)、UUO +阿托伐他汀治疗组 ,分别用免疫组化染色检测巨噬特异性抗原CD68和巨噬细胞集落刺激因子 (M -CSF)以确定肾间质巨噬细胞数和M -CSF的量 ,并常规查各组血脂。结果 单侧输尿管梗阻第 10d肾间质巨噬细胞积聚和M -CSF表达明显增加 ,阿托伐他汀治疗后二者均明显减少。模型组和治疗组巨噬细胞积聚程度与小管间质M -CSF表达呈正相关。各组血脂无显著性差异。结论 阿托伐他汀可显著减少肾间质巨噬细胞积聚程度 ,这可能与其下调小管间质M -CSF表达有关。
Objective To investigate the effect of atorvastatin on renal interstitium macrophage accumulation in rats with interstitial fibrosis and its possible mechanism. Methods One hundred and twenty rats were randomly divided into sham operation, unilateral ureteral obstruction (UUO) and UUO + atorvastatin treatment groups. Immunohistochemical staining was used to detect macrophage-specific antigen CD68 and macrophage colony stimulating factor M -CSF) to determine the amount of interstitial macrophages and the amount of M -CSF, and routinely examined for each group of lipids. Results Unilateral ureteral obstruction on the 10th day renal interstitial macrophage accumulation and M-CSF expression was significantly increased after atorvastatin treatment both significantly reduced. The accumulation of macrophages in model group and treatment group was positively correlated with the expression of M-CSF in tubulointerstitium. No significant difference in each group of lipids. Conclusion Atorvastatin can significantly reduce the accumulation of renal interstitial macrophages, which may be related to its down regulation of tubulointerstitial M-CSF expression.