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目的探讨儿童急性柯萨奇病毒感染阶段病毒性心肌炎Th1/Th2失衡和中药黄芪颗粒治疗的效果。方法按随机抽样设儿童急性柯萨奇病毒感染阶段病毒性心肌炎治疗1组,治疗2组与正常对照组,通过检查血清IFN-γ、IL-4、c Tn I、c Tn T水平及ECG,间接了解此类心肌炎Th1/Th2失衡和心肌损伤状态,观察用中药黄芪颗粒后Th1/Th2平衡恢复与心肌炎治愈率得到提高的变化。结果治疗前治疗1、2组IFN-γ水平低于对照组(P<0.05),IL-4水平高于对照组(P<0.05),显示Th1/Th2免疫优势向Th2倾斜,用黄芪颗粒治疗后,治疗2组IFN-γ上调,IL-4下移达到对照组水平(P均>0.05),Th1/Th2回到平衡,异常ECG消失率与c Tn I、c Tn T阴性转换率比治疗1组高(P均<0.01)。结论 Th1/Th2失衡也是该类心肌炎的表明用中药黄芪颗粒调节有效,心肌炎治愈率因此获得提高。
Objective To investigate the imbalance of Th1 / Th2 in viral myocarditis and the treatment of astragalus membranaceus in children with acute coxsackievirus infection. Methods Acute Coxsackie virus infected children with viral myocarditis were randomly divided into 1 group and 2 groups. The levels of IFN-γ, IL-4, cTn I, cTn T and ECG, Indirect understanding of such myocarditis Th1 / Th2 imbalance and myocardial damage, observed with Chinese medicine astragalus particles Th1 / Th2 balance recovery and cure rate of myocarditis increased. Results Before treatment, the levels of IFN-γ in treatment group 1 and 2 were lower than those in control group (P <0.05), and the levels of IL-4 in control group were higher than those in control group (P <0.05). Th1 / (P> 0.05), Th1 / Th2 back to balance, the rate of abnormal ECG disappearance and cTn I, c Tn T negative conversion rate than the treatment 1 group was higher (P <0.01). Conclusions Th1 / Th2 imbalance is also the type of myocarditis that is effectively treated with traditional Chinese medicine Astragalus Granules, the cure rate of myocarditis is thus improved.