霉菌的感染较广,特别是表浅霉菌感染在人群中非常普遍,因此在抗霉菌化学治疗上,迫切需要高效低毒的防治药物。四十年代Woolley认为苯并咪唑具有与嘌呤类似的结构,能抑制微生物的生长。Herrling等据此合成了氯苯咪唑(Chlormidazole)(1),临床上曾用作局部抗霉菌剂。1969年以后,出现了两种不同的咪唑类抗霉菌药物, Mold infection is wider, especially superficial mold infection is very common in the population, so in the anti-fungal chemotherapy, the urgent need for efficient and low toxicity of the prevention and treatment of drugs. Forty Woolley think benzimidazole has a purine similar structure, can inhibit the growth of microorganisms. Herrling et al accordingly synthesized Chlormidazole (1), which has been clinically used as a topical antimycotic. After 1969, two different imidazole antimycotic drugs appeared,