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慢性炎症,如风湿性关节炎、牙周炎等,是导致骨组织破坏的常见疾病。间充质干细胞,因具有多向分化及自我更新潜能,已成为骨再生的重要种子细胞。而慢性炎症微环境中,干细胞的特性将发生怎样的改变,以及其调控机制仍不清楚。microRNA(miRNA)是一类长约19~22个核苷酸的小分子非编码RNA,它们能够识别特定的靶基因,并负向调控其表达。本研究将正常组织与炎症组织来源的牙周膜干细胞比较后,发现炎症微环境中牙周膜干细胞的增殖能力增强而多向分化能力下降。在健康组织来源的牙周膜干细胞成骨分
Chronic inflammation, such as rheumatoid arthritis, periodontitis, etc., is a common disease that leads to the destruction of bone tissue. Mesenchymal stem cells, due to their multidirectional differentiation and self-renewal potential, have become important seed cells for bone regeneration. In the chronic inflammation microenvironment, the characteristics of stem cells will occur what changes, and its regulatory mechanism remains unclear. MicroRNAs (miRNAs) are small, non-coding RNAs about 19 to 22 nucleotides in length that recognize specific target genes and negatively regulate their expression. In this study, the normal tissue and inflammatory tissue-derived periodontal ligament stem cells compared to found in the inflammatory microenvironment, the proliferation of human periodontal ligament stem cells enhanced multipotential differentiation ability decreased. Periodontal ligament stem cells derived from healthy tissues are osteogenic