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目的探讨甲硝唑与结合雌激素软膏联合治疗老年阴道炎患者的治疗效果。方法选取2013年6月至2015年8月辽宁电力中心医院收治的老年阴道炎患者85例作为研究对象,按照治疗方式不同分为两组,治疗组43例患者接受甲硝唑及联合雌激素软膏联合治疗,对照组42例患者接受甲硝唑治疗,比较两组患者治疗效果、症状消失时间及复发情况。结果治疗组患者治疗的总有效率明显高于对照组,差异有统计学意义(χ~2=5.31,P<0.05);治疗后,治疗组患者的FSH、阴道健康评分、血清雌二醇(E2)明显优于对照组,差异均有统计学意义(均P<0.05);且患者的瘙痒消失、黏膜充血消失、白带恢复正常时间明显短于对照组,差异均有统计学意义(均P<0.05);对照组患者的复发率明显高于治疗组,差异有统计学意义(χ~2=4.65,P<0.05)。结论甲硝唑与联合雌激素软膏联合治疗老年阴道炎效果显著,能够促进患者较快恢复,改善阴道局部环境,降低该病复发率,不良反应少,安全可靠。
Objective To investigate the therapeutic effect of metronidazole combined with estrogen ointment in the treatment of senile vaginitis. Methods 85 elderly patients with vaginitis admitted from June 2013 to August 2015 in Liaoning Power Central Hospital were enrolled as study subjects and divided into two groups according to the different treatment methods. Forty three patients in the treatment group received metronidazole and combined estrogen ointment In combination therapy, 42 patients in the control group received metronidazole treatment. The treatment effect, the disappearance of symptoms and the recurrence were compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the control group (χ ~ 2 = 5.31, P <0.05). After treatment, FSH, vaginal health score, serum estradiol E2) was significantly better than the control group, the differences were statistically significant (both P <0.05); and the patient disappeared pruritus, mucosal congestion disappeared, leucorrhea returned to normal was significantly shorter than the control group, the difference was statistically significant (P <0.05). The recurrence rate of the control group was significantly higher than that of the treatment group (χ ~ 2 = 4.65, P <0.05). Conclusion Metronidazole combined with estrogen ointment in the treatment of senile vaginitis has a significant effect, which can promote the rapid recovery of patients, improve the vaginal local environment, reduce the recurrence rate of the disease, less adverse reactions, safe and reliable.