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用鼠疫菌感染流行和非流行区的旱獭，观察其感受性、临床表现、体液和细胞免疫等。结果表明，流行区和非流行区的旱獭对鼠疫的感受性和敏感性无明显差异；临床表现类似一般急性传染病，潜伏期短，有高烧、白细胞总数增加、核左移、淋巴肿大、及以充血、实质脏器充血、坏死为主要特征。初次感染的旱獭Ｆ１抗体第７天阳性率为３８．４％，再次感染第５天阳转率为１００％；血凝最高滴度初次感染为１：１２８０，再次感染１：４０９６０；３个月内，初次感染旱獭的ＭＰＩ＜１０，再次感染ＭＰＩ＜５；Ｅ－玫瑰花和淋转试验的观察与感染前有明显的差异；初次感染１０亿个活菌可全部致死旱獭，而存活的旱獭一年后可耐受１００亿活菌的攻击，个别可耐受７００亿活菌的攻击。实验结果对疫源地内旱獭鼠疫与人的流行病学关系及其流行病学作用具有重要意义。有助于喜马拉雅旱獭动物流行病的调查。
Marrow infected with epidemic and non-endemic areas of Yersinia pestis, observed its sensitivity, clinical manifestations, humoral and cellular immunity. The results showed that the susceptibility and sensitivity of marmot in endemic area and non-endemic area were similar to those in other areas. The clinical manifestations were similar to those of acute infectious diseases with short latent period, high fever, increased leukocyte count, left nucleus shift and lymph nodes, Congestive, real organs congestion, necrosis as the main feature. The first infection of marmot F1 antibody positive rate of 38.4% on the 7th day, 5 days after re-infection positive rate of 100%; the highest titer of the initial infection of blood clot 1: 1280, re-infection 1: 40960; 3 months MPI <10 and MPI <5 were again found in the first infection of Marmota, but there was a significant difference between the observation of the E-rose and the transformation test before infection; the first infection of one billion live bacteria could all cause death to the Marmota, while the surviving Marmot One year later it can tolerate 10 billion viable microbes and individually tolerate 70 billion live microbes. The experimental results are of great significance to the epidemiological relationship between plague and human beings in the foci and their epidemiological effects. Helps to investigate Himalayan marmot animal epidemics.