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UBAP1基因是在鼻咽癌 9p最小共同缺失区内新克隆的鼻咽癌候选抑瘤基因 ,通过采用病例 对照研究方法 ,对 10 5例鼻咽癌患者和 183例正常人UBAP1基因的 5个单核苷酸多态 (SNPs)用测序法进行了分型 ,在实验过程中 ,偶然发现了一个新的SNP位点 ,并已登录至dbSNP (登录号 :rs3135 92 9) .经相关分析发现 ,位于UBAP1基因第 6外显子中的SNPrs10 4 95 5 7与鼻咽癌发病存在显著相关性 ,基因型GG和GC的相对危险度分别为 1 6 4和 1 31.实验结果进一步支持了UBAP1基因与鼻咽癌的发生发展可能存在密切关系 ,SNPrs10 4 95 5 7由于处在UBAP1基因下游 3′非翻译区 ,其多态类型可能在某种程度上影响UBAP1基因的表达调控 ,从而与鼻咽癌发病相关
UBAP1 gene is a nasopharyngeal cancer candidate tumor suppressor gene cloned in the minimal common deletion region of 9p in nasopharyngeal carcinoma. By using a case-control study, UBAP1 gene was transfected into 5 human nasopharyngeal carcinoma patients and 183 normal human UBAP1 Nucleotide polymorphisms (SNPs) were genotyped by sequencing. During the experiment, a new SNP site was discovered by accident and was logged into dbSNP (accession number: rs3135 92 9) .According to the correlation analysis, SNPrs10 4 95 5 7 located in exon 6 of UBAP1 gene was significantly associated with the pathogenesis of NPC, and the relative risk of genotypes GG and GC was respectively 1 6 4 and 1 31. The experimental results further supported that UBAP1 gene There may be a close relationship with the occurrence and development of nasopharyngeal carcinoma. SNPrs10 4 95 5 7 Due to being located in the 3 ’untranslated region downstream of UBAP1 gene, its polymorphism may affect the expression regulation of UBAP1 gene to a certain extent, Cancer related