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在胎儿发育期,人体造红血细胞主要合成胎儿Hb(α_2γ_2)而在出生后不久,几乎全部转换为合成成年Hb (α_2β_2)。这种密切联系的γ和β基因活性的个性发生性变化,也见于大多数灵长类及少数其它哺乳动物。在山羊和绵羊的胚胎,胚哈Hb到成年Hb的转换期在妊娠130天,并于几周内完成。作者为了研究Hb合成转变的调控机理,在实验组把妊娠100天、能合成HbA(α_2β_2~A)的胎羊造血细胞移植到合成HbB (α_2β_2~B)的成年绵羊体内时,用等电聚焦法证实,移植前后者只有一种Hb B合成的移植后成年绵羊血内同时有2种血红蛋白(HbA,HbB)合成;此外,尚有少量的HbF合成。在自体移植对照组,即预先抽出骨髓细胞、再用致死量射线照射,在2小时后把抽出的自体细
During fetal development, human erythroblasts mainly synthesize fetal Hb (α_2γ_2) and soon after birth, almost all convert to synthetic adult Hb (α_2β_2). The closely related changes in the individuality of the activity of the gamma and beta genes are also seen in most primates and in a few other mammals. In goat and sheep embryos, embryo Hb to adult Hb transitional period is 130 days of gestation and is completed within a few weeks. In order to study the regulation mechanism of Hb synthesis and translocation, in the experimental group, when fetal sheep hematopoietic cells capable of synthesizing HbA (α_2β_2 ~ A) at 100 days of gestation were transplanted into adult sheep for synthesizing HbB (α_2β_2 ~ B) Method confirmed that there was only one type of hemoglobin (HbA, HbB) synthesis in the blood of adult sheep after transplanting. There was a small amount of HbF synthesis. Autologous transplantation control group, that is, pre-extracted bone marrow cells, and then lethal dose irradiation, after 2 hours to extract the self-thin