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目的:观察内镜下止血联合抗幽门螺旋杆菌(Hp)四联疗法治疗胃溃疡合并出血的效果及对患者Hp根除率和不良反应的影响。方法:抽取2018年1月至2019年12月于漯河医学高等专科学校第二附属医院接受治疗的204例胃溃疡合并出血患者为研究对象，按照随机数字表法将其分为观察组与对照组，每组102例。两组均给予基础治疗，对照组加用常规抗Hp四联疗法治疗，观察组在对照组治疗基础上予以内镜下止血治疗。比较两组围治疗期指标、临床疗效、治疗前及治疗6周后的炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、氧化应激和核因子-κB(NF-κB)]与血清胃肠功能指标(胃泌素、生长抑素、胃动素)水平。记录治疗过程中的不良反应发生情况。结果:观察组止血成功率、Hp根除率、总有效率高于对照组(n P<0.05)，再出血率低于对照组(n P<0.05)。治疗6周后，两组IL-6、TNF-α、NF-κB、生长抑素水平均较治疗前下降(n P均<0.05)；而胃泌素、胃动素较治疗前上升(n P<0.05)，且观察组各指标变化高于对照组(n P0.05)。n 结论:内镜下止血联合抗Hp四联疗法治疗胃溃疡合并出血，可尽早成功止血，并降低再出血率，提高临床疗效，为四联疗法打下良好基础，有利于炎性因子水平的降低及胃肠功能的恢复。“,”Objective:To observe the efficacy of endoscopic hemostasis combined with anti-Helicobacter pylori (Hp) quadruple therapy in the treatment of gastric ulcer with bleeding.Methods:A total of 204 patients with gastric ulcer complicated by bleeding who were treated in the Second Affiliated Hospital of Luohe Medical College from January 2018 to December 2019 were selected as subjects. And they were divided into observation group and control group according to the random number table method, with 102 cases in each group. Both groups were given basic treatment. Additionally, control group was given conventional anti-Hp quadruple therapy, and observation group was given endoscopic hemostasis on the basis of treatment of control group. The peri-treatment indicators, clinical efficacy, and inflammatory factors, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), oxidative stress and nuclear factor-κB (NF-κB), and serum gastrointestinal function indexes including gastrin (GAS), somatostatin (SS), motilin (MTL) before treatment and after 6 weeks of treatment were compared between the two groups. And the incidences of adverse reactions of the two groups during treatment were recorded.Results:The success rate of hemostasis, Hp eradication rate, and total effective rate in observation group were significantly higher than those in control group (n P<0.05), and the rebleeding rate was significantly lower than that in control group (n P<0.05). After 6 weeks of treatment, the levels of IL-6, TNF-α, NF-κB, and SS in the two groups significantly decreased (alln P<0.05), and the GAS and MTL increased significantly, compared with the levels of above indicators before treatment (n P<0.05); and the changes of these indexes in observation group were significantly higher than those in control group (n P0.05).n Conclusions:Endoscopic hemostasis combined with anti-Hp quadruple therapy for gastric ulcer complicated by bleeding can successfully stop bleeding through endoscopy as soon as possible, reduce rebleeding rate, improve clinical efficacy, lay a good foundation for quadruple therapy, and help the decreases of inflammatory factors and recovery of gastrointestinal function.