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应用流式细胞仪和OKT McAb分析了30例急性甲型肝炎外周血T细胞亚群变化,并观察其中5例的动态变化。结果表明,病程极期患者CD_4亚群百分率明显降低;CD_6亚群百分率升高;CD_4/CD__8比值明显降低。这些变化可能与HAV侵害淋巴系统及应激性免疫调动有关。
The changes of T lymphocyte subsets in 30 patients with acute hepatitis A were analyzed by flow cytometry and OKT McAb, and the dynamic changes in 5 of them were observed. The results showed that the percentage of CD_4 subpopulations was significantly lower in patients with extreme stage of disease, the percentage of CD_6 subpopulation was increased, and the ratio of CD_4 / CD_8 was significantly decreased. These changes may be HAV infiltration of the lymphatic system and stress related to immune transfer.