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3组12只兔双眼行玻璃体切除术,分别于一眼玻璃体内注入0.5、1.0、2.0mg去炎松悬液,另一眼注入眼用平衡盐液。观察术后28天内眼底及ERGb波和28天时视网膜结构的变化。注入各剂量的去炎松在28天时均未完全吸收,0.5、1.0mg组用药眼ERGb波在各时间点与对照眼及术前无显著差异(P>0.05);2.0mg组用药眼较术前无显著差异(P>0.05),较对照眼有轻度升高(t=3.3589,P>0.05)。光镜及电镜下视网膜结构无损害。表明玻璃体切除后使用有效剂量的去炎松对视网膜仍是安全的
Three groups of 12 rabbits underwent vitrectomy, respectively, in an intravitreal injection of 0.5,1.0,2.0mg triamcinolone suspension, the other eye into the eye balanced salt solution. The changes of fundus and ERGb wave and the retinal structure at 28 days postoperatively were observed. Injection of each dose of triamcinolone are not completely absorbed in 28 days, 0.5, 1.0mg group ERGb eye wave at each time point with the control eye and preoperative no significant difference (P> 0.05); There was no significant difference between the 0mg group and the control group (P> 0.05), which was slightly higher than that of the control group (t = 3.3589, P> 0.05). Light and electron microscopy under the retina structure without damage. This suggests that vitrectomy is still safe for the retina with an effective dose of triamcinolone