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目的:探讨中国汉族急性冠状动脉综合征(ACS)患者的易感性基因。方法:采用聚合酶链式反应/限制性片段长度多态性分析中国汉族108例患者(ACS组)和90例健康者(对照组)的4个候选基因,7个多态性。结果:ACS组基质金属蛋白酶-2(MMP-2)(-1306C/T)C等位基因频率与对照组比较差异有统计学意义(P<0.05),2组间3种基因型(CC、CT和TT)分布差异有统计学意义(P<0.05),而ACS组MMP-2(-1575G/A,-790G/T和-735C/T)、基质素-1(5A6A)、G蛋白β3亚单位(825C/T)和连接蛋白37(CX37)基因多态性(1019C/T)基因型分布和等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论:MMP-2基因(-1306C/T)多态性可能与中国汉族人群ACS有关,MMP-2基因-1306C等位基因可能是ACS遗传易感性的基因标志之一。
Objective: To investigate the susceptibility genes in Chinese Han patients with acute coronary syndrome (ACS). Methods: Four candidate genes and seven polymorphisms of 108 Chinese Han patients (ACS group) and 90 healthy controls (control group) were analyzed by polymerase chain reaction / restriction fragment length polymorphism. Results: The frequency of MMP - 2 (-1306C / T) C allele in ACS group was significantly lower than that in control group (P <0.05). The genotypes of CC, (P <0.05), while the expression of MMP-2 (-1575G / A, -790G / T and -735C / T), basal-1 (5A6A) There were no significant differences in genotype distribution and allele frequency between subunit (825C / T) and connexin 37 (CX37) gene polymorphism (1019C / T) and control group (P> 0.05). CONCLUSION: The polymorphism of MMP-2 gene (-1306C / T) may be related to ACS in Chinese Han population. The MMP-2 gene-1306C allele may be one of the genetic markers of ACS genetic susceptibility.