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目的了解不同年龄小儿胃酸度变化的特点。方法用便携式pH动态监测仪(Medtronic)对982例不同年龄儿童进行空腹胃pH值测定。结果空腹胃pH值在新生儿期(128例)、~1岁组(288例)、~3岁组(182例)、~7岁组(210例)、~15岁组(174例)分别为2·32±0·90、1·92±0·58、1·66±0·63、1·70±0·48、1·59±0·47。2周不到的新生儿(77例)与大于2周的新生儿(51例)空腹胃pH值分别为2·30±0·92、2·35±0·88,其差异无统计学意义。新生儿组与各组间的差异有统计学意义(P均<0·001);~1岁组与各组间的差异也有统计学意义(P均<0·001)。,而~3岁组、~7岁组和~15岁组之间的差异则无统计学意义(P>0·05)。结论新生儿期胃内已呈酸性环境,但其胃pH值高于婴幼儿及年长儿;随着年龄的增长,胃pH值逐渐降低,1岁以后已接近成人水平;提示酸相关性疾病可发生于包括新生儿在内的儿童。
Objective To understand the characteristics of gastric acidity changes in children of different ages. Methods A total of 982 children of different ages underwent fasting gastric pH measurement with a portable pH dynamic monitor (Medtronic). Results Fasting gastric pH value was significantly higher in the neonatal period (128 cases), in the first year group (288 cases), in the third year group (182 cases), in the seventh year group (210 cases) Was 2.32 ± 0.90, 1.92 ± 0. 58, 1.66 ± 0.63, 1.70 ± 0.48, 1.59 ± 0.47.2 weeks after birth (77 (P <0.05), and fasting gastric pH value of newborns (51 cases) more than 2 weeks were 2.30 ± 0.92 and 2.35 ± 0.88, respectively, with no significant difference. Neonatal group and the differences between the groups were statistically significant (P all <0.001); ~ 1 year old group and the differences between the groups were also statistically significant (P <0.001). , But there was no significant difference between ~ 3 years old group, ~ 7 years old group and ~ 15 years old group (P> 0.05). Conclusion The neonatal stomach has an acidic environment, but its gastric pH value is higher than that of infants and elders. With age, the gastric pH value gradually decreases and reaches the adult level after 1 year of age. It suggests that acid-related diseases It can happen to children, including newborns.