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目的:探讨妊娠期糖尿病患者炎性因子、晚期氧化蛋白产物(AOPP)、同型半胱氨酸(Hcy)、血管细胞黏附分子1(VCAM-1)表达及妊娠结局变化。方法:选择浙江省台州医院于2019年1月至2020年1月收治的妊娠期糖尿病103例作为观察组；另选择同期在该院分娩的正常妊娠87例作为对照组，均采用全自动生化分析仪检测空腹血糖(FPG)和空腹胰岛素(FINS)；采用ELISA法测定肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)水平、AOPP和VCAM-1水平；采用循环酶法测定Hcy水平。结果:观察组FPG[(8.34±1.25)mmol/L]、FINS[(9.75±0.89)U/L]，高于对照组[(4.89±0.67)mmol/L、(5.93±0.45)U/L](n t＝23.088、36.297，n P<0.05)。观察组血清TNF-α[(21.63±3.25)ng/L]、hs-CRP[(6.34±1.29)mg/L]、IL-6[(147.32±28.39)ng/L]，均高于对照组[(8.72±1.84)ng/L、(2.17±0.73)mg/L、(87.96±12.41)ng/L](n t＝32.861、26.744、18.091，均n P<0.05)；观察组血清AOPP[(53.21±9.89)μg/L]、Hcy[(11.23±1.36)μmol/L]、VCAM-1[(94.27±15.46)μg/L]，均高于对照组[(25.48±6.18)μg/L、(8.41±1.28)μmol/L和(62.18±6.52)μg/L](n t＝22.674、14.627、18.047，均n P<0.05)。观察组不良妊娠结局发生率(29.13%)低于对照组(4.60%)(χn 2＝19.313，n P<0.05)。n 结论:妊娠期糖尿病患者存在明显炎性反应，且血清AOPP、Hcy和VCAM-1水平明显升高，妊娠结局不良。“,”Objective:To investigate the expression of inflammatory factors, advanced oxidation protein products (AOPP), homocysteine (Hcy), vascular cell adhesion molecule 1 (VCAM-1) and the clinical significance of pregnancy outcome in patients with gestational diabetes.Methods:From January 2019 to January 2020, 103 cases of gestational diabetes in Taizhou Hospital of Zhejiang province were selected as observation group, and 87 normal pregnant women in Taizhou Hospital of Zhejiang province from January 2019 to January 2020 were selected as control group.The fasting blood glucose (FPG) and fasting insulin (FINS) were measured by automatic biochemical analyzer.The levels of tumor necrosis factor-α(TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), AOPP and VCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). The Hcy level was measured by circulating enzyme method.Results:The FPG [(8.34±1.25)mmol/L] and FINS [(9.75±0.89)U/L] in the observation group were higher than those in the control group [(4.89±0.67)mmol/L and (5.93±0.45)U/L] (n t=23.088, 36.297, all n P<0.05). The serum levels of TNF-α [(21.63±3.25)ng/L], hs-CRP [(6.34±1.29)mg/L], IL-6 [(147.32±28.39)ng/L] in the observation group were higher than those in the control group [(8.72±1.84)ng/L, (2.17±0.73)mg/L and (87.96±12.41)ng/L] (n t=32.861, 26.744, 18.091, all n P<0.05). The serum levels of AOPP [(53.21±9.89)μg/L], Hcy [(11.23±1.36)μmol/L] and VCAM-1 [(94.27±15.46)μg/L] in the observation group were higher than those in the control group [(25.48±6.18)μg/L, (8.41±1.28)μmol/L and (62.18±6.52)μg/L] (n t=22.674, 14.627, 18.047, all n P<0.05). The incidence of adverse pregnancy outcome in the observation group (29.13%) was lower than that in the control group (4.60%) (χn 2=19.313, n P<0.05).n Conclusion:The patients with gestational diabetes have obvious inflammatory reaction, higher serum levels of AOPP, Hcy and VCAM-1, and poor pregnancy outcome.