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肝细胞癌的发生是多种遗传学事件累积的结果 [1]。 p16抑癌基因在人类肝癌失活频率较高，失活机制主要受 DNA甲基化的影响 [2]。 5-脱氧杂氮胞苷（ 5- Aza- 2- deoxycytidine, 5- Aza- cdR）是 DNA甲基转移酶（ DNA methyltransferase）抑制剂，在体外实验，它通过去甲基化机制
The occurrence of hepatocellular carcinoma is the result of accumulation of various genetic events [1]. The frequency of inactivation of p16 tumor suppressor gene in human liver cancer is high, and the inactivation mechanism is mainly affected by DNA methylation [2]. 5-Aza-2-deoxycytidine (5-Aza-cdR) is an inhibitor of DNA methyltransferase (DNA methyltransferase) in vitro. It passes the demethylation mechanism.