近年来发现,在人和哺乳动物体内,存在着一种内源性洋地黄素样物质(Endogenous digitalis like Substances),它主要存在于下丘脑和心脏内,具有强大的利尿和强心作用。我们既往的工作证明,内源性洋地黄素与外源性洋地黄一样,可以抑制Na-K ATP酶,竞争抑制~3H-哇巴因与受体的结合,可与某些强心甙抗体产生交叉反应。最近,我们又发现,自发性高血压的大鼠(SHR),其心脏和血浆中内源性洋地黄素显著升高,与其血压呈正相关的关系,这提示内源 In recent years, it has been found that in humans and mammals, there is an endogenous digitalis like substance, which is mainly present in the hypothalamus and the heart and has strong diuretic and cardiotonic effects. Our previous work demonstrated that endogenous digitalis, like exogenous digitalis, inhibits Na-K ATPase and competitively inhibits the binding of ~ 3H-ouabain to receptors and binds to certain cardiac glycoside antibodies Produce cross-reaction. Recently, we found that spontaneously hypertensive rats (SHRs) had significantly increased endogenous digitalis and their blood pressure in their hearts and plasma, suggesting a positive correlation with their blood pressure, suggesting that endogenous