大量研究表明过多的活性氧簇与帕金森病(Parkinson’sdisease,PD)的发生、发展密切相关。PD患者机体长期处于氧化应激状态 ,去除活性氧簇在脑内的毒性作用便成为治疗该病的一条重要途径 ,而抗氧化剂谷胱甘肽在此过程中发挥着极其关键的作用。提高谷胱甘肽在脑内的浓度或应用谷胱甘肽的类似物、前体来防治PD及其它神经退行性疾病 ,已经成为当前药物研制的一个重要靶点 A large number of studies have shown that excessive reactive oxygen species and Parkinson’s disease (Parkinson’s disease, PD) is closely related to the occurrence and development. Long-term oxidative stress in PD patients is one of the important ways to remove the toxic effects of reactive oxygen species in the brain. Antioxidant glutathione plays an extremely important role in this process. Increasing the concentration of glutathione in the brain or using glutathione analogs and precursors to prevent and treat PD and other neurodegenerative diseases has become an important target of current drug development