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血管内皮生长因子B是血管内皮生长因子家族的一员,长期以来血管内皮生长因子B被认为是血管内皮生长因子家族中作用最模糊的成员之一。近年来研究表明,血管内皮生长因子B通过与2种受体结合,可产生一系列生物学效应,例如改善心肌缺血、神经保护、调节脂质代谢等。这些研究结果使得人们越来越关注血管内皮生长因子B的生物学功能及其在疾病中的应用。对血管内皮生长因子B的结构和生物学功能及相关信号通路进行综述。
Vascular endothelial growth factor B is a member of the vascular endothelial growth factor family and has long been considered as one of the most vague members of the vascular endothelial growth factor family. In recent years, studies have shown that vascular endothelial growth factor B through a combination of two receptors, can produce a series of biological effects, such as improving myocardial ischemia, neuroprotection, regulating lipid metabolism. These findings make people pay more and more attention to the biological function of vascular endothelial growth factor B and its application in the disease. The structural and biological functions of vascular endothelial growth factor B and related signaling pathways are reviewed.