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目的:观察消旋卡多曲颗粒治疗婴幼儿急性水样泻的疗效及安全性。方法:对我院门诊2008年10月—2009年5月的112例急性水样泻患儿,随机分成观察组和对照组,对照组予蒙脱石散、妈咪爱、补液等综合治疗,观察组在此基础上加用消旋卡多曲颗粒1.5mg·kg-1治疗,tid,治疗3d后开始观察疗效。结果:治疗组总有效率92.8%(52/56),显著高于对照组78.6%(44/56),差异有统计学意义(χ2=7.56,P<0.01);观察组平均治疗时间(3.4±0.7)d,对照组平均治疗时间(4.7±1.0)d,两组比较差异有统计学意义(t=8.25,P<0.01)。结论:消旋卡多曲治疗婴幼儿急性水样腹泻,可明显缩短病程,疗效显著,且未发现与药物有关的不良反应,安全性好。
Objective: To observe the efficacy and safety of racecadotril granules in the treatment of infantile acute watery diarrhea. Methods: A total of 112 cases of acute watery diarrhea in our hospital from October 2008 to May 2009 were randomly divided into observation group and control group. The control group was treated with montmorillonite powder, mommy love, rehydration, The observation group on this basis plus racecadotril particles 1.5mg · kg-1 treatment, tid, 3d after treatment began to observe the effect. Results: The total effective rate in the treatment group was 92.8% (52/56), significantly higher than that in the control group (78.6%, 44/56) (χ2 = 7.56, P <0.01) ± 0.7) d. The mean treatment time in the control group (4.7 ± 1.0) d was statistically significant (t = 8.25, P <0.01). Conclusion: Racecadotril treatment of acute watery diarrhea in infants and young children, can significantly shorten the course of the disease, the effect was significant, and no drug-related adverse reactions, safety.