基因的变异在子宫内膜异位症(EMs)的发生和发展中有很重要的作用。研究发现EMs的发生有家族遗传倾向,一级亲属的患病率高于一般人群。某些卵巢癌的候选基因在EMs中也能检测到。孕激素受体(PR)的基因在异位内膜中有变异,无PR-B表达。氧化应激反应也可能诱发EMs发生,使用抗氧化剂能阻止诱发兔EMs。环境毒素二噁英(dioxin)可能会激活体内的某些化学酶系而诱发EMs。 Gene mutations in the occurrence and development of endometriosis (EMs) have a very important role. The study found that the occurrence of EMs family genetic predisposition, the prevalence of first-degree relatives than the general population. Candidate genes for some ovarian cancers are also detectable in EMs. Progesterone receptor (PR) gene in the ectopic endometrium have mutations, no PR-B expression. Oxidative stress may also induce the development of EMs. Antioxidants can prevent the induction of EMs in rabbits. Environmental toxin dioxin may activate certain chemical enzymes in the body to induce EMs.