【摘 要】
：
The androgen receptor (AR) is a pleiotrophic transcription factor that regulates expression of a large number of genes involved in many diverse cellular processes.The AR activation pathways have been studied extensively.However,the molecular mechanism and
【机 构】
：
Department of Biochemistry and Molecular Biology,Mayo Clinic College of Medicine, Rochester, MN 5590
论文部分内容阅读
The androgen receptor (AR) is a pleiotrophic transcription factor that regulates expression of a large number of genes involved in many diverse cellular processes.The AR activation pathways have been studied extensively.However,the molecular mechanism and biological significance of AR inhibitory signals remain poorly understood.Mukhopadhyay et aL have now identified the nuclear matrix protein scaffold attachment factor B1 (SAFB1) as a novel AR corepressor.
其他文献
The 12th International Symposium of Spermatology continued the excellent tradition of this meeting since its inception in 1969 when the first Symposium was held in Italy under the Chairmanship of Professor Baccio Baccetti.This unique Symposium is held eve
The Sixth International Conference on the Epididymis (Epididymis Ⅵ:Networks in the Epididymis,Basic and Clinical Research) was held between October 31 and November 3 2014 in Shanghai,China.rnThis was the second Chinese venue for this meeting,following the
Androgens have important effects on multiple organ systems,which play critical roles in the regulation of a myriad of male sexual,somatic,and behavioral functions critical to lifelong health.Androgen deficiency is a multisystem syndrome,presenting with ty
The International Prostate Forum (IPF) originally started with three urologydepartments in Japan, Turkey, and the United States.The forum emphasized discussions and presentations of new knowledge in all areas of prostate diseases with an early emphasis on
Lessons from the occupational arena demonstrate the potential of industrial chemicals to damage human testicular function.An important but still unresolved question is whether low-level xenobiotic exposure of the general population poses a hazard.In this
There is a lot to learn from transnational research collaboration,and the Prostate Cancer Foundation (PCF) is dedicated to building bridges around the world to address complex scientific and clinical issues related to the development of improved diagnosti
Large scale exome sequencing studies have revealed regions of the genome,which contribute to the castrate resistant prostate cancer (CRPC) phenotype.1-3 Such studies have identified mutations in genes,which may have diagnostic/prognostic potential,or whic
The prostate cancer foundation (PCF) is committed to the facilitation of global knowledge exchange as a mechanism for more rapidly discovering and developing new medicines and treatments for prostate cancer (PCa) patients worldwide.For the past 3 years,PC