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众所周知，丙型肝炎易慢性化，慢性化率高达50%~80%。一旦慢性化，病毒很少发生自发清除，且极易向肝硬化、肝癌方向发展，而抗病毒治疗是控制疾病进展的关键环节。影响丙型肝炎抗病毒因素的研究报道提示，其与病毒、宿主、治疗方案等有一定的关系。为了能更早期、更有效、更经济地控制病程进展，提高治疗效果，该文总结了目前影响丙型肝炎抗病毒疗效的相关因素，较为全面地阐明了这些因素对抗病毒疗效影响的原由，以利临床治疗。“,”As is well-known,the progress of hepatitis C is prone to be chronic,with chronic rate up to 50%-80%. Once become chronic,the viruses seldom autoclean,and may easily develop into cirrhosis and hepatic cancer,and antiviral therapy is the key to control the progress of the disease. It has been reported that influence factors of antiviral effect to hepatitis C virus is correlated with virus itsitself, host and therpay. Therefore,in order to earlier,more effectively,more economically control the disease progression,here sum-marizes the influencing factors of the antiviral effect,and comprehensively expounds the reasons,in order to facilitate the clinical treatment.