论文部分内容阅读
目的:探讨高胆红素血症新生儿血β2-微球蛋白(β2-MG)的变化及临床意义。方法:将2012年9~11月收治的30例高胆红素血症新生儿列为实验组,将同期在本院分娩的30例生理性黄疸新生儿列为对照组,分别测定血β2-MG、肌酐(Cr)及尿素氮(BUN),并进行对照。结果:实验组患儿血β2-MG水平明显高于对照组(t=8.683,P<0.01),且随胆红素水平的升高,血β2-MG也随之增高,总胆红素及间接胆红素水平与血β2-MG呈正相关(r=0.947、0.955,P<0.01)。两组血Cr、BUN均在正常范围,无统计学意义(P>0.05)。结论:高胆红素血症患儿存在肾功能损伤,血β2-MG水平与Cr、BUN相比可以在早期更敏感的反映新生儿肾功能损伤程度。
Objective: To investigate the changes of serum β2-microglobulin (β2-MG) in neonates with hyperbilirubinemia and its clinical significance. Methods: Thirty newborns with hyperbilirubinemia admitted from September to November in 2012 were enrolled as the experimental group. Thirty newborn infants with physiological jaundice in our hospital were enrolled as the control group. Blood β2- MG, creatinine (Cr) and urea nitrogen (BUN) were measured and compared. Results: The level of β2-MG in the experimental group was significantly higher than that in the control group (t = 8.683, P <0.01). With the increase of bilirubin level, β2-MG also increased, Indirect bilirubin levels were positively correlated with serum β2-MG (r = 0.947, 0.955, P <0.01). The blood Cr and BUN in the two groups were within the normal range, with no statistical significance (P> 0.05). CONCLUSION: There is renal dysfunction in children with hyperbilirubinemia. Compared with Cr and BUN, serum β2-MG levels may be more sensitive to early neonatal renal damage.