This paper reviews the rapid progress in the field of high-throughput modeling based on the Materials Genome Initia-tive, and its application in the discovery and design of lithium battery materials. It offers examples of screening, optimiza-tion and design of electrodes, electrolytes, coatings, additives, etc. and the possibility of introducing the machine leaing method into material design. The application of the material genome method in the development of lithium battery materials provides the possibility to speed up the upgrading of new candidates in the discovery of lots of functional materials.