细胞癌基因(C-onc)是单拷贝的结构基因,在生物进化过程中高度保守。正常状况下,对机体有重要生理功能。但一旦被激活后便大量表达,产生过量的可能有转化作用的蛋白。许多文献报道,癌细胞的某些C-onc常常发生DNA放大与重排,包括易位、缺失和插入。对于N-ras癌基因定位研究及探究它在某些肿瘤细胞内基因放大现象,已有不 The cell oncogene (C-onc) is a single-copy structural gene that is highly conserved during biological evolution. Under normal conditions, the body has important physiological functions. However, once it is activated, it is expressed in large quantities, producing an excess of proteins that may have a transforming effect. Many literatures reported that certain C-onc of cancer cells often undergo DNA amplification and rearrangement, including translocations, deletions, and insertions. The study of N-ras oncogene localization and its gene amplification in certain tumor cells