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目的：观察得康口服液拮抗５－Ｆｕ引起小鼠食量、体重下降及ＷＢＣ减少的作用。方法：将６０只雄性昆明种小白鼠随机分为３组，观察组用得康口服液与５－Ｆｕ联合灌饲小白鼠，空白对照组单纯灌饲５－Ｆｕ，正常对照组灌饲生理盐水，连续给药１０天后测定小鼠食量、体重及ＷＢＣ总数。结果：观察组小鼠日均食量（６８．９±１２．１）ｇ，体重为（２４．１±１．４）ｇ，ＷＢＣ总数（６．９±２．１）×１０９／Ｌ；与空白对照组比较有显著差异（Ｐ＜０．０１）。结论：得康口服液可以拮抗５－Ｆｕ引起的小鼠食量、体重下降及ＷＢＣ减少的不良反应
OBJECTIVE: To observe the effect of Dekang Oral Solution on food intake, weight loss and WBC reduction induced by 5-Fu in mice. Methods: Sixty male Kunming mice were randomly divided into three groups. The observation group was fed with 5-Fu with Dekang oral solution and the blank control group with 5-Fu. The normal control group was infused with normal saline After 10 days of continuous administration, the mice food intake, body weight and WBC count were determined. Results: The average daily food intake (68.9 ± 12.1) g, body weight (24.1 ± 1.4) g and total number of WBC (6.9 ± 2.1) × 109 / L in the observation group were There was significant difference between the blank control group (P <0.01). Conclusion: Dekang oral liquid can antagonize 5-Fu-induced mice food intake, weight loss and WBC decreased adverse reactions