论文部分内容阅读
为预防浅表膀胱癌(PT_0—T_1)术后复发,采用聚维酮(PVP)作为溶剂,行阿霉素膀胱内灌注23例(A组),另用生理盐水作为溶剂行膀胱内灌注21例以作对照(B组),两组疗程及灌注方式均相同。A组平均随访13个月,B组平均随访14个月。A组无肿瘤复发,B组复发9例(42.8％),两组比较有非常显著性差异,表明用PVP作为抗癌药的溶剂能更有效地防止膀胱癌的复发。A组在灌注后24～36小时仍可在尿中测到有效药物浓度,比B组延长12～24小时,平均尿药回收率可达96.6％,说明不会增加机体的吸收。
In order to prevent the recurrence of superficial bladder cancer (PT_0-T_1), Povidone (PVP) was used as the solvent. Intravesical instillation of doxorubicin was performed in 23 patients (group A) and saline was used as the intravesical instillation of 21 Cases for control (B group), two groups of treatment and perfusion method are the same. The patients in group A were followed up for an average of 13 months. The patients in group B were followed up for an average of 14 months. There was no tumor recurrence in group A, and 9 cases (42.8%) in group B. There was a significant difference between the two groups, indicating that PVP can effectively prevent the recurrence of bladder cancer as a solvent of anticancer drug. Group A 24 ~ 36 hours after infusion can still be measured in the urine of effective drug concentration than the B group extended 12 to 24 hours, the average urinary drug recovery of up to 96.6%, indicating that does not increase the body’s absorption.