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作者调查了经受组胺i．v．H2－受体拮抗剂治疗的1200个病例。美国东南部五个州的四十所医院参与了这项药物使用评价（DUE）。每所医院的一名药剂师，除提供医院背景资料外，还以统一的形式同时连续对30例已开始使用i．v．西米替丁、雷尼替丁或法莫替丁的成年病人进行观察。除了病人的年龄及处方者的医学专业外，具体的DUE标准包括病历中记载的药物使用理由；根据病人肾功能情况调配剂量；其它同时服用的胃肠病药物；药剂师的介入；口服药的同时应用；不良反应的发生；H2拮抗剂与能影响其它药物血药浓度的药物的配伍应用及胃液PH值监察的应用。i．v．H2－拮抗剂的治疗往往由内科和外科医师开始的，并且多数的评价对象属为防止胃粘膜损害而接受这一疗法的病人。根据预测肌酐清除率，34％的病人需要调整剂量，而这些病人中只有49％作了剂量调整。百分之四十的病人在服用至少一种口服药的同时，开始i．v．H2拮抗剂的治疗，几乎四分之一的病人接受了另加的、以治疗消化系统疾病及其相关症状的药物。调查表明，三种H2拮抗剂的不良反应相似。调查指出了在临床使用H2拮抗剂的方法上，几个有疑问的方面。
The authors investigated the histamine response to histamine i. v. 1200 cases treated with H2-receptor antagonists. Forty hospitals in five states in the southeastern United States participated in the drug use evaluation (DUE). A pharmacist in each hospital, in addition to providing hospital background information, also started using 30 patients simultaneously in a uniform manner. v. Cimetidine, ranitidine or famotidine adult patients were observed. In addition to the age of the patient and the medical profession of the prescriber, the specific DUE criteria include the reasons for the use of the drug documented in the medical record; the dose to be administered based on the renal function of the patient; other concurrent gastrointestinal medications; the intervention of the pharmacist; Application; Adverse reactions; H2 antagonist and drugs can affect the drug concentration of other drugs compatibility and application of gastric juice PH value monitoring. i. v. The treatment of H2-antagonists often begins with internal medicine and surgeons, and the majority of patients are patients who receive the therapy to prevent gastric mucosal damage. According to the prediction of creatinine clearance, 34% of patients need to adjust the dose, and only 49% of these patients were dose-adjusted. Forty percent of patients start with i while taking at least one oral medication. v. H2 antagonist treatment, almost a quarter of patients received additional medications to treat digestive diseases and their associated symptoms. Surveys show that the three H2 antagonists have similar adverse reactions. The survey pointed out several ways in which to use H2 antagonists clinically.